MACITENTAN is a Schedule H drug.
Macitentan lowers blood pressure in your lungs, helping your heart pump blood more efficiently.
Macitentan is an endothelin receptor antagonist. It works by suppressing the action of endothelin, a natural substance that tightens the blood vessels and prevents normal blood flow in patients who have pulmonary hypertension.


MACITENTAN is generally used to treat: Pulmonary Hypertension

Frequently Asked Questions

Q: Is it safe on my liver?
A: Not Safe

Q: Is it safe on my kidney?
A: Check with your Doctor first

Q: Can I take it with alcohol?
A: Not Safe

Q: Is it safe for children?
A: Ask your doctor

Q: Can it be taken during pregnancy?
A: Dangerous – Studies indicate Human-Fetal Risk

How Do I Take It?

Route of Administration: Oral


  • Do not use macitentan if you are pregnant or think you might be pregnant.
  • You should not use macitentan if you are allergic to it.
  • If you are the parent or caregiver of a female child taking this medicine, talk to the child’s doctor once you notice any signs of puberty (breast development or pubic hair), even if menstrual periods have not yet begun.
  • Follow all directions on your prescription label. Do not take this medicine in larger or smaller amounts or for longer than recommended.Do not crush, chew, or break a macitentan tablet. Swallow it whole.
  • While using macitentan, you may need frequent blood tests.
  • Do not take extra medicine to make up the missed dose.
  • Do not have unprotected sex while taking macitentan. Do not increase your dose or use this drug more often or for longer than prescribed.

Symptoms of Overdosage

MACITENTAN over-dosage can result in: Difficulty Breathing

Common Side-Effects

MACITENTAN : Edema, Muscle Pain, Joint Pain, Throat Soreness, Head Headache, Fever, Chills, Runny Nose, Body Pain, Dark Colored (brown) Urine, Abdomen Pain, Frequent Urge To Urinate, Difficulty Urinating, Pain With Urination, Lower Back Pain

Serious Side-Effects

MACITENTAN : Bronchitis, Anemia, Infertility, Noisy Breathing, Decreased Urination, Hands Swelling, Feet Swelling, Fingers Swelling, Fatigue (tiredness), Easy Bleeding, Difficulty Breathing, Weight Gain, Eyes Yellow Eyes, Chest Discomfort, Ankles Swelling, Shortness Of Breath

Rare Side-Effects

MACITENTAN : Skin Rash, Itchy Skin, Dizziness

Disease Interactions

MACITENTAN can interfere with: Acute Liver Failure, Anemia, Congestive Heart Disease

Technical Classification


Storage Conditions

Room Temperature (Between 15 To 25 C)

Available Alternatives

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