Maprotiline is an antidepressant. Maprotiline affects chemicals in the brain that may be unbalanced in people with depressive disorders. Maprotiline is used to treat major depressive disorder, depressive neurosis, manic depressive illness, or anxiety related to depression. It may help improve mood and feelings of well-being. This medication belongs to a class of medications called tetracyclic antidepressants.


MAPROTILINE HYDROCHLORIDE is generally used to treat: Bulimia Nervosa, Depression, Ulcer, Duodenal, Enuresis, Pain, Panic Disorder

Frequently Asked Questions

Q: Is it safe on my liver?
A: Not Safe

Q: Is it safe on my kidney?
A: Check with your Doctor first

Q: Can I take it with alcohol?
A: Not Safe

Q: Is it safe for children?
A: Not Advised for age < 6yrs

Q: Can it be taken during pregnancy?
A: Considered as Generally Safe – not enough studies to prove risk

Q: Is it safe to take for someone breastfeeding?
A: Not Safe

How Do I Take It?

Route of Administration: Oral


  • It may cause dizziness or drowsiness, do not drive a car or operate machinery and get up slowly from bed while taking this medication.
  • Avoid alcohol consumption.
  • It may increase suicidal tendency in children and teenagers, if so consult with your doctor.
  • Before taking maprotiline, tell your doctor or pharmacist if you are allergic to it or to tricyclic antidepressants (such as nortriptyline); or if you have any other allergies.
  • Maprotiline may cause a condition that affects the heart rhythm (QT prolongation). QT prolongation can rarely cause serious fast/irregular heartbeat and other symptoms that need medical attention right away.
  • This medication may make you more sensitive to the sun. Limit your time in the sun. Avoid tanning booths and sunlamps. Use sunscreen and wear protective clothing when outdoors.
  • If you have diabetes, this drug may make it harder to control your blood sugar levels. Monitor your blood sugar levels regularly and tell your doctor of the results. Your doctor may need to adjust your diabetes medication, exercise program, or diet.
  • During pregnancy, this medication should be used only when clearly needed. If you are planning pregnancy, become pregnant, or think you may be pregnant, immediately discuss with your doctor the benefits and risks of using this medication during pregnancy.
  • This medication passes into breast milk and the effect on a nursing infant is unknown. Consult your doctor before breast-feeding.

Symptoms of Overdosage

MAPROTILINE HYDROCHLORIDE over-dosage can result in: Drowsiness, Hallucinations, Irregular Heartbeat, Fainting, Difficulty Breathing, Seizures (uncontrollable Jerking Of Limbs)

Common Side-Effects

MAPROTILINE HYDROCHLORIDE : Skin Rash, Itchy Skin, Seizure, Constipation, Nausea, Vomit, Weight Loss (unintentional), Unusual Behavior

Rare Side-Effects

MAPROTILINE HYDROCHLORIDE : Confusion, Fainting, Difficulty Urinating, Hallucinations, Irregular Heartbeat, Throat Soreness, Eyes Yellow Eyes

Disease Interactions

MAPROTILINE HYDROCHLORIDE can interfere with: Myocardial Infarction, Alcoholism, CNS Disorder, Glaucoma, Urinary Retention, Hypotension, Hyperthyroidism, Pheochromocytoma, Depression, Bipolar Disorder, Ischemic Heart Disease, Vomiting, Neutropenia, Diabetes Mellitus, Acute Liver Failure, Acute Renal Failure, Schizophrenia, Tardive Dyskinesia

Technical Classification


Storage Conditions

Room Temperature (Between 15 To 25 C)

Available Alternatives

What are the other drugs with similar Ingredients?