SILTUXIMAB is a Schedule H drug.
Siltuximab inhibits a certain protein in the body called interleukin-6. High levels of IL-6 can cause an overgrowth of cells in the lymph system. It treats a rare disease called multicentric Castleman’s disease(MCD). Siltuximab blocks a certain natural substance that affects the immune MCD can increase your risk of certain cancers by changing the way your immune system works.Siltuximab is not for use in people who have human immunodeficiency virus (HIV) or human herpesvirus-8.system.


SILTUXIMAB is generally used to treat: Castleman’s Disease
SILTUXIMAB can address symptoms like: Fever, Fatigue (tiredness), Night Sweats

Frequently Asked Questions

Q: Is it safe on my liver?
A: Check with your Doctor first

Q: Is it safe on my kidney?
A: Not Safe

Q: Can I take it with alcohol?
A: Not Safe

Q: Is it safe for children?
A: Ask your doctor

Q: Can it be taken during pregnancy?
A: Not enough studies to prove Risk – Ask your Doctor

Q: Is it safe to take for someone breastfeeding?
A: Not Safe

How Do I Take It?

Route of Administration: IV (Intravenous)


  • You should not use siltuximab if you have a severe infection.
  • You should not use siltuximab if you are allergic to it.
  • Siltuximab can lower blood cells that help your body fight infections.
  • Your blood will need to be tested often.
  • Your siltuximab treatments may be delayed based on the results of these tests.
  • Do not receive a "live" vaccine while using siltuximab. The vaccine may not work as well during this time, and may not fully protect you from disease.

Symptoms of Overdosage

SILTUXIMAB over-dosage can result in: Difficulty Breathing

Common Side-Effects

SILTUXIMAB : Skin Rash, Itchy Skin, Dry Skin, Upper Respiratory Tract Infections, Pruritus, Weight Gain, Runny Nose, Throat Soreness, Sneezing, Abdomen Pain, Abdomen Bloating Or Fullness, Body Pain, Chills, Confusion, Fever, Cough, Head Headache, Nausea, Vomit, Back Pain, Chest Pain, Dizziness, Dry Mouth, Fainting, Irregular Heartbeat, Rapid Breathing, Lightheadedness, Eyes Sunken Eyes, Decreased Appetite

Serious Side-Effects

SILTUXIMAB : Joint Pain, Muscle Pain, Eyes Blurred Vision, Blood Or Red Colored Urine, Gums Bleeding, Black (tar) Colored Stools, Difficulty Breathing, Slow Or Weak Urine Stream, Increased Thirst, Loss Of Appetite, Loss Of Voice, Nasal Congestion, Body Excessive Sweating, Abdomen Swelling, Hands Tingling, Weight Loss (unintentional), Body Loss Of Movement, Abdomen Painful Bowel Movements

Rare Side-Effects

SILTUXIMAB : Eyes Swelling, Face Swelling, Swollen Lips, Difficulty Swallowing, Chest Discomfort

Disease Interactions

SILTUXIMAB can interfere with: Bacterial Infection, Fungal Infection, Vaccination, Acute Liver Failure, Acute Renal Failure

Technical Classification


Storage Conditions

Refrigeration (Between 2 To 8 C)

Available Alternatives

What are the other drugs with similar Ingredients?