DORNASE ALFA is a Schedule H drug.
Dornase alfa is a synthetic protein that breaks down excess DNA in the pulmonary secretions of people with cystic fibrosis.Dornase alfa is used to improve lung function in people with cystic fibrosis by thinning pulmonary secretions and reducing the risk of respiratory tract infections.Dornase Alfa belongs to a group of drugs called mucolytics which help to thin mucus in the lungs so it is easier to cough out. This medication is used to improve breathing and reduce the risk of lung infections in people with cystic fibrosis. It is used along with other treatments for this disease.Cystic fibrosis is a condition in which a thick mucus is formed in the lungs and breathing passages. The mucus blocks the airways and increases the chance of lung infections. The infections then cause the mucus to become even thicker, making it more difficult to breathe. Dornase alfa will not cure cystic fibrosis. However, when it is used every day, it helps make breathing easier and reduces the number of serious lung infections that require treatment with antibiotics.


DORNASE ALFA is generally used to treat: Cystic Fibrosis
DORNASE ALFA can address symptoms like: Cough, Wheezing, Shortness Of Breath, Abdomen Pain, Fatigue (tiredness), Weakness (generalized)

Frequently Asked Questions

Q: Is it safe on my liver?
A: Check with your Doctor first

Q: Is it safe on my kidney?
A: Check with your Doctor first

Q: Can I take it with alcohol?
A: Not Safe

Q: Is it safe for children?
A: Not Advised for age < 5yrs

Q: Can it be taken during pregnancy?
A: Considered as Generally Safe – not enough studies to prove risk

Q: Is it safe to take for someone breastfeeding?
A: Check with your Doctor first

How Do I Take It?

Route of Administration: Oral


  • Do not use dornase alfa if you have an allergy to dornase alfa, Chinese Hamster Ovary cell products, or any component of dornase alfa.
  • Use dornase alfa exactly as directed by your doctor.
  • If you do not understand these directions, ask your pharmacist, nurse, or doctor to explain them to you.
  • Do not dilute or mix the dornase alfa solution with any other drugs in the nebulizer. Mixing of dornase alfa with other drugs could lead to changes in the actions of the medications.
  • Do not dilute or mix dornase alfa with other agents in the nebulizer at the same time.
  • Ampules of dornase alfa do not contain a preservative. It is intended for one-time use only. Once opened, the entire contents of the ampule must be used or discarded.
  • Do not use any dornase alfa solution that is cloudy or discolored.
  • Dornase alfa should be used on a regular basis to get the most benefit.

Symptoms of Overdosage

DORNASE ALFA over-dosage can result in: Difficulty Breathing

Common Side-Effects

DORNASE ALFA : Laryngitis, Body Pain, Cough, Throat Soreness, Fever, Runny Nose, Neck Enlarged Or Swollen Glands, Loss Of Voice, Eyes Itching, Eyes Swelling

Serious Side-Effects

DORNASE ALFA : Stomach Pain, Indigestion, Chest Pain, Difficulty Breathing, Difficulty Swallowing, Belching, Heartburn, Abdomen Discomfort

Rare Side-Effects

DORNASE ALFA : Skin Rash, Itchy Skin

Technical Classification


Storage Conditions

Refrigeration (Between 2 To 8 C)

Available Alternatives

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