TOLCAPONE is a Schedule H drug.
Tolcapone is used together with other medicines to treat symptoms of Parkinson’s disease, This medication is a catechol-O-methyl transferase (COMT) inhibitor, prescribed for Parkinson’s disease along with levodopa/carbidopa.


TOLCAPONE is generally used to treat: Parkinson’s Disease
TOLCAPONE can address symptoms like: Body Muscle Cramps Or Spasms (painful), Muscle Stiffness, Body Loss Of Movement, Loss Of Coordination, Unusual Facial Expression, Difficulty Talking, Body Difficulty Walking

Frequently Asked Questions

Q: Is it safe on my liver?
A: Not Safe

Q: Is it safe on my kidney?
A: Check with your Doctor first

Q: Can I take it with alcohol?
A: Not Safe

Q: Is it safe for children?
A: Ask your doctor

Q: Can it be taken during pregnancy?
A: Not enough studies to prove Risk – Ask your Doctor

Q: Is it safe to take for someone breastfeeding?
A: Check with your Doctor first

How Do I Take It?

Route of Administration: Oral


  • You should not use tolcapone if you have liver disease.
  • Do not use tolcapone if you have used an MAO inhibitor in the past 14 days.
  • You should not use tolcapone if you are allergic to it.
  • Follow all directions on your prescription label. Your doctor may occasionally change your dose.
  • Do not take tolcapone in larger or smaller amounts or for longer than recommended.
  • Do not take tolcapone as your only Parkinson’s medication. Tolcapone must be used in combination with carbidopa and levodopa.Tolcapone is usually taken three times a day. The first dose is taken with your first daily dose of carbidopa and levodopa. The second and third doses of tolcapone are taken 6 and 12 hours later.
  • Follow your doctor’s dosing instructions very carefully.
  • Do not stop using tolcapone suddenly, or you could have unpleasant withdrawal symptoms.
  • Do not take extra medicine to make up the missed dose.This medication may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.
  • Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. Get up slowly and steady yourself to prevent a fall.
  • Drinking alcohol with tolcapone can cause side effects.

Symptoms of Overdosage

TOLCAPONE over-dosage can result in: Vomit, Dizziness

Common Side-Effects

TOLCAPONE : Gas, Diarrhoea, Heartburn, Muscle Pain, Dizziness, Drowsiness, Nausea, Loss Of Appetite, Loose Motion, Body Muscle Cramps Or Spasms (painful), Difficulty Sleeping, Frightening Dreams, Abdomen Pain, Cough, Fainting, Fever, Nasal Congestion, Head Headache, Runny Nose, Sneezing, Throat Soreness, Vomit, Chills, Body Loss Of Movement, Frequent Falls, Confusion, Body Discomfort, Chest Pain, Loss Of Balance, Dry Mouth, Constipation, Body Excessive Sweating, Frequent Urge To Urinate, Muscle Stiffness

Serious Side-Effects

TOLCAPONE : Hemorrhage, Depression, Impotence, Hallucinations, Blood Or Red Colored Urine, Chest Pain, Hyperactive Behavior, Difficulty Breathing, Irregular Heartbeat, Mood Swings, Easy Bleeding

Rare Side-Effects

TOLCAPONE : Blood Pressure, Low, Agitation, Feet Burn, Pain With Urination, Chest Discomfort, Difficulty Urinating, Slow Thinking, Difficulty Concentrating, Restless Or Irritability, Joint Pain, Redness, Neck Pain, Stiff Neck

Disease Interactions

TOLCAPONE can interfere with: Hypotension, Psychosis

Technical Classification


Storage Conditions

Room Temperature (Between 15 To 25 C)

Available Alternatives

What are the other drugs with similar Ingredients?