RIOCIGUAT is a Schedule H drug.
Riociguat lowers blood pressure in your lungs, helping your heart pump blood more efficiently.Riociguat can improve your ability to exercise and help prevent PAH from getting worse.Riociguat works by relaxing and widening the blood vessels in your lungs so blood can flow more easily. Decreasing high blood pressure in the lungs allows your heart and lungs to work better and improves your ability to exercise.This increases the blood supply to the lungs, which reduces the workload of the heart.


RIOCIGUAT is generally used to treat: Pulmonary Hypertension
RIOCIGUAT can address symptoms like: Fatigue (tiredness), Loss Of Appetite, Joint Pain, Weight Gain, Abdomen Swelling, Shortness Of Breath, Fainting, Dizziness, Chest Pain, Palpitations (fluttering In Chest)

Frequently Asked Questions

Q: Is it safe on my liver?
A: Check with your Doctor first

Q: Is it safe on my kidney?
A: Check with your Doctor first

Q: Can I take it with alcohol?
A: Not Safe

Q: Is it safe for children?
A: Ask your doctor

Q: Can it be taken during pregnancy?
A: Dangerous – Studies indicate Human-Fetal Risk

How Do I Take It?

Route of Administration: Oral


  •  Do not use if you are pregnant.
  • Avoid getting pregnant while taking riociguat and for at least 1 month after your last dose. Do not have unprotected sex.
  • You should not use riociguat if you are allergic to it.
  • Do not take riociguat within 24 hours before or after taking sildenafil
  • Tell your doctor right away if you miss a menstrual period or think you may have become pregnant during treatment.
  • Follow all directions on your prescription label. Your doctor may occasionally change your dose to make sure you get the best results.
  • Do not take this medicine in larger or smaller amounts or for longer than recommended.Riociguat is usually taken 3 times per day. Space your doses 6 to 8 hours apart.
  • You may need frequent medical tests to help your doctor determine how long to treat you with riociguat.
  • Avoid driving or operating machinery until you know how the medicine will affect you.
  • Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. Get up slowly and steady yourself to prevent a fall.Avoid taking an antacid within 1 hour before or after you take riociguat. Some antacids can make it harder for your body to absorb riociguat.
  • Smoking can make riociguat less effective. Tell your doctor if you start or stop smoking while you are taking this medicine.
  • Your dose needs may need to be changed
  • It increases your risk of bleeding. Be careful while shaving, cutting fingernails or toenails, or using sharp objects.
  • Do not take Riociguat if you are also taking a nitrate medicine such as nitroglycerin to treat high blood pressure or heart disease.

Symptoms of Overdosage

RIOCIGUAT over-dosage can result in: Difficulty Breathing

Common Side-Effects

RIOCIGUAT : Diarrhoea, Nosebleeds, Indigestion, Constipation, Head Headache, Dizziness, Lightheadedness, Fatigue (tiredness), Black (tar) Colored Stools, Abdomen Bloating Or Fullness, Cough, Irregular Heartbeat, Pounding Heart (pulse), Vagina Bleeding, Weight Gain, Abdomen Pain, Difficulty Breathing, Vomit

Serious Side-Effects

RIOCIGUAT : Heartburn, Blood Pressure, Low, Anemia, Confusion, Head Headache, Bloody Or Red Colored Vomit

Rare Side-Effects

RIOCIGUAT : Skin Rash, Itchy Skin

Disease Interactions

RIOCIGUAT can interfere with: Hypotension, Hypertension, Acute Liver Failure, Acute Renal Failure

Technical Classification


Storage Conditions

Room Temperature (Between 15 To 25 C)

Available Alternatives

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